What Is This?
SS-31 (Elamipretide) is a small peptide designed to go straight to the inner membrane of mitochondria. It sticks to cardiolipin, a special fat in that membrane. When mitochondria are damaged, they leak harmful molecules and make less energy - SS-31 is studied for stabilizing that membrane and reducing the damage.
What Do Researchers Study?
Labs measure whether SS-31 lowers mitochondrial ROS (harmful oxygen byproducts), preserves ATP output, and protects cardiomyocytes, myotubes, kidney tubule cells, and neurons under low-oxygen or oxidative stress in culture. Seahorse metabolic assays and ROS dyes are common readouts.
Common Research Uses
- Mitochondrial ROS reduction assays with fluorescent probes
- Cardiomyocyte and skeletal muscle cells under low-oxygen conditions
- Mitochondrial disease cell models (e.g. Barth syndrome fibroblasts)
- Mitochondrial membrane potential and ATP output tests
- Oxidative stress challenge studies across multiple cell types
What the Science Is Looking At
- Stabilizes the inner mitochondrial membrane by binding to cardiolipin
- Preserves ATP production in stressed cell cultures
- Reduces damaging reactive oxygen species from dysfunctional mitochondria
- Studied across heart, muscle, kidney, and brain cell types under oxidative challenge
- One of the best-characterized mitochondria-targeted peptides in cell bioenergetics research
How It Works - In Plain English
Membrane Stabilizer
Binds cardiolipin and helps keep the folded cristae structures of the inner mitochondrial membrane intact. Disrupted cardiolipin is a hallmark of failing mitochondria in culture.
Energy Protection
Improves electron transport chain organization so cells maintain ATP output even under oxidative or low-oxygen stress. Seahorse XF assays are often used to confirm this.
Lower ROS
Decreases leak of harmful reactive oxygen species from damaged mitochondria - measurable with MitoSOX and similar dyes.
Cell-Type Flexibility
Because mitochondria work similarly across cell types, SS-31 is tested in cardiac, neuronal, renal, and muscle cultures to compare protective effects on energy metabolism.
Product Specifications
| Compound | SS-31 (Elamipretide) |
|---|---|
| Quantity | 50 mg per vial |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC) |
| Storage | -20 C |
Order SS-31
99%+ Purity • Third-Party Tested • COA Included • Ships Canada 1-2 Days
Multi-vial deal: 2+ vials of this peptide = $10 off per vial!