What Is This?
PT-141 (bremelanotide) is a cyclic heptapeptide that activates melanocortin receptors - especially MC3R and MC4R found in hypothalamic and limbic brain regions - with less activity on pigmentation-related MC1R than related compounds like MT-II. Researchers use it as a standard reference ligand for studying melanocortin receptor pharmacology in neuronal cultures and binding assays.
What Do Researchers Study?
Melanocortin peptides are studied for their role in brain cell circuits involved in energy balance, autonomic signaling, and neuropeptide cascades. PT-141 is a key reference compound for receptor binding, selectivity profiling, and cAMP second-messenger assays in hypothalamic neuron cultures.
Common Research Uses
- MC3R/MC4R receptor binding and selectivity assays
- Hypothalamic and limbic neuron signaling models
- Melanocortin cAMP second-messenger cascade research
- Energy balance and appetite-related neuropeptide pathway studies
- Comparative melanocortin ligand profiling vs MT-II and related peptides
What the Science Is Looking At
- Targets specific brain receptors (MC3R/MC4R) involved in appetite and autonomic signaling
- Less focused on tanning/pigmentation (MC1R) than related melanocortin compounds
- Standard reference ligand for melanocortin receptor binding and selectivity studies
- Used to study how melanocortin activation affects energy balance pathways in neuronal cultures
- Cyclic structure provides receptor affinity suited for reproducible binding assays
How It Works • ” In Plain Terms
Works in the Brain, Not the Skin
Unlike tanning peptides, PT-141 acts mainly on brain receptors • ” not skin pigment cells. It's studied for effects on desire, arousal, and mood pathways in the central nervous system.
Flips On Motivation Circuits
Activates MC3R and MC4R receptors in the hypothalamus • ” brain regions tied to appetite, drive, and sexual behavior. Researchers study how this changes signaling in those circuits.
Less Tanning, More Brain Focus
Designed to have less effect on skin-darkening (MC1R) than Melanotan 2, while keeping strong activity on the brain receptors that matter for behavioral research.
Supports Energy Balance Research
Also studied for how it influences appetite-regulating hormones and metabolic signaling • ” not just behavioral pathways.
Product Specifications
| Compound | PT-141 (melanocortin agonist) |
|---|---|
| Quantity | 10 mg per vial |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC) |
| Storage | -20 C, light-protected |
Order PT-141
99%+ Purity • Third-Party Tested • COA Included • Ships Canada 1-2 Days
Multi-vial deal: 2+ vials of this peptide = $10 off per vial!