What Is This?
MOTS-c is a 16-amino-acid peptide encoded by DNA inside mitochondria (the cell's power plants). When cells face metabolic stress, MOTS-c can travel to the nucleus and turn on genes involved in sugar and fat metabolism - like an internal exercise signal.
What Do Researchers Study?
Researchers study MOTS-c for how it activates AMPK (the cell's energy sensor), improves insulin sensitivity markers in muscle cells, and turns on exercise-related gene programs in cultured myotubes and metabolic cell lines. It is also used to explore how mitochondrial DNA encodes signaling peptides that talk back to the nucleus.
Common Research Uses
- AMPK phosphorylation and energy-sensor pathway experiments
- Insulin sensitivity and glucose uptake tests in muscle cells
- Exercise-mimicking metabolic gene expression research
- Mitochondria-to-nucleus signaling and retrograde communication studies
- Aging, diabetes, and metabolic stress cell culture models
What the Science Is Looking At
- Activates AMPK - a master switch for energy use and fat burning in cells
- Muscle cell cultures show improved insulin sensitivity and glucose uptake markers
- Turns on gene programs similar to endurance exercise in cultured myotubes
- Key reference for aging, diabetes, and exercise biology research in vitro
- Represents a rare class of peptide encoded by mitochondrial DNA - not the cell nucleus
How It Works - In Plain English
Energy Sensor (AMPK)
Turns on AMPK, which helps cells take up more glucose and shift metabolism toward fat oxidation. Researchers confirm activation by phospho-AMPK Western blots.
Exercise-Like Signals
Causes muscle cells to activate genes normally associated with endurance training - including mitochondrial and oxidative metabolism pathways.
Mitochondria to Nucleus
Under metabolic stress, MOTS-c can travel to the cell nucleus and influence metabolic and antioxidant gene transcription - a retrograde signaling pathway.
Metabolic Stress Response
Cells release more MOTS-c when facing glucose or energy stress, making it a useful tool for studying how mitochondria communicate distress to the rest of the cell.
Product Specifications
| Compound | MOTS-c (mitochondrial peptide) |
|---|---|
| Quantity | 40 mg per vial |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC) |
| Storage | -20 C |
Order MOTS-c
99%+ Purity • Third-Party Tested • COA Included • Ships Canada 1-2 Days
Multi-vial deal: 2+ vials of this peptide = $10 off per vial!