What Is This?
Epithalon (Ala-Glu-Asp-Gly), also called Epitalon, is a four-amino-acid peptide developed in Russia as part of the Khavinson bioregulator research program. It is one of the most discussed short peptides in aging-cell research, studied for how it may influence telomerase (the enzyme that maintains chromosome end caps), pineal gland clock genes, and antioxidant enzyme defenses in cultured cells.
What Do Researchers Study?
Researchers examine Epithalon in aging and senescent cell cultures for effects on telomerase activity (measured by TRAP assays), melatonin synthesis genes in pinealocytes, and antioxidant enzymes like superoxide dismutase (SOD) and catalase. Gene expression profiling is commonly used to map which aging-related pathways shift after treatment.
Common Research Uses
- Telomerase activity assays (TRAP) in aging and dividing cells
- Pineal gland and melatonin pathway research in pinealocyte cultures
- Antioxidant enzyme (SOD, catalase, glutathione) studies under oxidative stress
- Longevity, senescence, and replicative aging cell culture endpoints
- Khavinson bioregulator peptide comparison studies
What the Science Is Looking At
- Studied for activating telomerase markers in aging and senescence cell cultures
- Examined for restoring melatonin rhythm genes in aging pineal cell cultures
- Cell studies report upregulation of antioxidant enzymes (SOD, catalase) under oxidative stress
- Popular reference in Russian bioregulator and longevity research literature
- Often paired with Pinealon in multi-peptide aging cell research programs
How It Works - In Plain English
Telomerase Research
Published cell culture work explores whether Epithalon increases telomerase activity - the enzyme that rebuilds telomere caps on chromosome ends. TRAP assays are the standard readout.
Pineal and Sleep Genes
Studied for effects on melatonin production enzymes (AANAT, HIOMT) and pineal gland function markers in aging pinealocyte cultures.
Antioxidant Defense
Treated cells often show higher superoxide dismutase and catalase levels - enzymes that neutralize harmful free radicals during oxidative stress challenge.
Bioregulator Concept
Khavinson peptides like Epithalon are proposed to work by normalizing age-shifted gene expression patterns directly in cells - a mechanism researchers test with transcriptome analysis.
Product Specifications
| Compound | Epithalon (Ala-Glu-Asp-Gly tetrapeptide) |
|---|---|
| Quantity | 50 mg per vial |
| Form | Lyophilized powder |
| Purity | 99%+ (HPLC) |
| Storage | -20 C |
Order Epithalon
99%+ Purity • Third-Party Tested • COA Included • Ships Canada 1-2 Days
Multi-vial deal: 2+ vials of this peptide = $10 off per vial!