SLU-PP-332
ERR-alpha agonist probe for mitochondrial biogenesis research.
What Researchers Study
SLU-PP-332 is a first-in-class synthetic agonist of estrogen-related receptor alpha (ERR-alpha), governing mitochondrial biogenesis, fatty acid oxidation, and oxidative metabolism gene programs.
Primary Research Applications
- ERR-alpha transcriptional program studies
- Mitochondrial biogenesis myocyte assays
- Oxidative fibre-type gene expression research
- Metabolic disease cell models
Benefits Researchers Are Exploring (in simple terms)
Mechanisms Under Investigation
ERR-alpha Agonism
Selective activation of nuclear genes controlling mitochondrial biogenesis and beta-oxidation.
PGC-1alpha Induction
Elevates PGC-1alpha and mitochondrial density markers in myocyte cultures.
Exercise Mimetic
Shifts myocyte gene expression toward oxidative, endurance-associated profiles.
Reconstitution Reference (how to mix it for lab use)
| Common vial size | 5 mg |
| Reconstitution | 1-2 mL BAC water |
| Storage | -20 C, desiccated |
| Solubility | May require dilute acetic acid pre-dissolution per lab SOP |
Dosing Schedule Options from Research
Example Options Used in Studies
- Myocyte cultures: 24-72 hour exposure for gene expression endpoints
- Research literature: daily oral or systemic schedules over 3-6 weeks in published studies.
- Exercise-comparison studies: 4-week parallel protocol references
- Emerging compound - protocol standardisation still evolving in literature
100-Unit Insulin Syringe Conversion Chart
Reconstitution used for these calculations: Calculate concentration (mg/mL) from the reconstitution table above. U-100 insulin syringes: 100 units = 1 mL total volume.
Important: We have already done all the math for you. U-100 insulin syringes are marked in "units" (100 units = 1 mL). Just draw the exact number of units listed below for each dose. No calculations required on your end.
| Dose (mg) | Units on 100-unit syringe (pre-calculated) |
|---|---|
| Use: Units = (desired mg / mg per mL concentration) × 100. See primary literature for exact values. | |
These unit amounts assume the exact concentration listed above. Always double-check your own reconstitution volume against the chart.
Safe Research Cycle Guidelines
Example Cycle References from Research Literature
- Consult published research literature and your institution's approved protocols for recommended cycle lengths, titration, and recovery periods specific to this compound.
Research Notes
SLU-PP-332 is a novel tool compound distinct from ERR-beta/gamma receptor research ligands.
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