Semax
A Russian-developed peptide researched for supporting brain growth factors (like BDNF) and protecting neurons in lab models.
What Researchers Study
Semax is a small 7-amino-acid peptide based on a piece of ACTH (a natural hormone). Scientists made it more stable. It is heavily studied in Russian and international research for increasing BDNF (brain-derived neurotrophic factor) and other growth factors that help neurons survive and form new connections. It is often looked at in models of brain stress or low oxygen.
Primary Research Applications
- Measuring BDNF and other brain growth factors
- Low-oxygen (ischemia) brain cell protection tests
- How well neurons make new connections and branches
- Protecting brain cells from over-excitation damage
Benefits Researchers Are Exploring (in simple terms)
- In neuronal cultures, it is associated with higher levels of BDNF, NGF, and GDNF — important for neuron survival and plasticity.
- Helps brain cells stay alive and healthy in low-oxygen or "stroke-like" lab models.
- Supports markers of new synaptic connections and dendritic spine growth in hippocampal cells.
- Shows protective effects against excitotoxicity (too much stimulation) and oxidative damage in neuron studies.
- Frequently studied alongside Selank for cognitive and stress-related brain research.
Mechanisms Under Investigation
Growth Factor Boost
It is linked to increased production of BDNF and related neurotrophins that help neurons grow and stay healthy.
Protection in Stress
In oxygen-glucose deprivation models, treated neurons show better survival and less cell death.
Better Connections
It increases proteins like synaptophysin and helps form more dendritic spines — signs of improved neuron communication.
Reconstitution Reference (how to mix it for lab use)
| Common vial sizes | 5 mg and 11 mg |
| Reconstitution | Add 1-2 mL bacteriostatic water per 5 mg vial. |
| Storage | Freeze the powder. Protect mixed solution from light. |
| Variants | N-Acetyl Semax and Amidate versions exist for different stability needs in research. |
Dosing Schedule Options from Research
Example Options Used in Studies
- Neuron culture: 24-72 hour exposure at appropriate concentrations while measuring BDNF or survival markers.
- Daily research model: Draw **10-50 units** (100-500 mcg) daily on 100-unit syringe for 14-28 days; 5 mg vials for shorter pilots, 11 mg for longer studies. Use 1-2 mL BAC for 5-10 mg/mL.
- Paired protocols: Often run with Selank in 2-4 week cognitive or neuroprotection experiments.
- Amidate forms: Used when researchers need longer stability in extended protocols.
100-Unit Insulin Syringe Conversion Chart
Reconstitution used for these calculations: 5 or 11 mg vial + 1-2 mL bacteriostatic water = 5-10 mg/mL (standard for Semax).
Important: We have already done all the math for you. U-100 insulin syringes are marked in "units" (100 units = 1 mL). Just draw the exact number of units listed below for each dose. No calculations required on your end.
| Dose (mg) | Units on 100-unit syringe (pre-calculated) |
|---|---|
| 100-250 mcg daily | 10-25 units (0.10-0.25 mL) at 10 mg/mL |
| 500 mcg daily | 50 units (0.50 mL) |
These unit amounts assume the exact concentration listed above. Always double-check your own reconstitution volume against the chart.
Safe Research Cycle Guidelines
Example Cycle References from Research Literature
- Typical research cycle: 14-28 days on at 100-500 mcg daily, minimum 2-4 weeks off.
- Paired with Selank for 2-4 weeks.
- Key: Approved protocols.
Research Notes
Semax is one of the most published neuropeptides from Russian research. Different chemical variants (like Amidate) are chosen depending on how long the experiment needs the peptide to remain active.
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