Selank
A synthetic peptide from Russian research studied for calming effects on the brain and immune system in lab models.
What Researchers Study
Selank is a small 7-amino-acid peptide created in Russia as a more stable version of a natural immune peptide called tuftsin. Researchers study it because it appears to influence GABA (a calming brain chemical), help stabilize natural pain-relieving peptides called enkephalins, and affect how the immune system and nervous system talk to each other.
Primary Research Applications
- Looking at calming brain signals (GABA)
- Stress and anxiety-related brain chemistry tests
- How immune signals affect brain cells
- Reference compound for certain brain pharmacology studies
Benefits Researchers Are Exploring (in simple terms)
- May help modulate calming brain pathways (GABA) in neuronal cell studies.
- Researchers have looked at its ability to slow the breakdown of enkephalins (natural "feel good" peptides).
- Shows effects on inflammatory signals (like IL-6 and TNF-alpha) in brain-immune cell co-culture models.
- Often studied for potential supportive effects in stress-response research.
- Frequently compared or paired with Semax because they target overlapping but different brain pathways.
Mechanisms Under Investigation
Calming Brain Signals
It appears to influence GABA receptor subunits and enzymes involved in serotonin metabolism in neuronal cultures.
Protecting Natural Peptides
It is studied for inhibiting the enzyme that breaks down enkephalins, helping them last longer in biochemical tests.
Brain-Immune Connection
In co-culture models, it can change levels of inflammatory signals that brain and immune cells send to each other.
Reconstitution Reference (how to mix it for lab use)
| Common vial size | 11 mg |
| Reconstitution | Add 1.1 mL bacteriostatic water = 10 mg per mL. |
| Storage | Freeze the powder. Once mixed, keep in the fridge. |
| Note | Some research looks at intranasal (through the nose) delivery in models. |
Dosing Schedule Options from Research
Example Options Used in Studies
- Neuronal cell studies: Short acute exposure (minutes to a few hours) at lower concentrations for signalling readouts.
- Longer research model: Draw **10-50 units** (100-500 mcg) on 100-unit syringe daily for 14-28 days. Use 11 mg vial + 1.1 mL BAC = 10 mg/mL concentration.
- Paired with Semax: Many labs run Selank and Semax together in cognitive or stress-related protocols for 2-4 weeks.
- Biochemical assays: Used at concentrations that inhibit enkephalinase in test tube or cell extract experiments.
100-Unit Insulin Syringe Conversion Chart
Reconstitution used for these calculations: 11 mg vial + 1.1 mL bacteriostatic water = 10 mg/mL concentration (standard for Selank).
Important: We have already done all the math for you. U-100 insulin syringes are marked in "units" (100 units = 1 mL). Just draw the exact number of units listed below for each dose. No calculations required on your end.
| Dose (mg) | Units on 100-unit syringe (pre-calculated) |
|---|---|
| 100 mcg daily | 10 units (0.10 mL) |
| 250 mcg daily | 25 units (0.25 mL) |
| 500 mcg daily | 50 units (0.50 mL) |
These unit amounts assume the exact concentration listed above. Always double-check your own reconstitution volume against the chart.
Safe Research Cycle Guidelines
Example Cycle References from Research Literature
- Typical research cycle: 14-28 days on at 100-500 mcg daily, minimum 2-4 weeks off.
- Paired: 2-4 weeks with Semax.
- Key: Approved protocols.
Research Notes
Selank comes from Russian research and is often studied alongside Semax. The two peptides are related but appear to work through somewhat different mechanisms.
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