PT-141 (Bremelanotide)
MC3R/MC4R agonist for central melanocortin pharmacology research.
What Researchers Study
PT-141 is a cyclic heptapeptide melanocortin agonist with selectivity toward MC3R and MC4R over pigmentation-related MC1R. It is a standard reference ligand in melanocortin receptor binding and CNS pharmacology studies.
Primary Research Applications
- MC3R/MC4R binding and selectivity assays
- Hypothalamic neuron signalling models
- Melanocortin second-messenger cascade research
- Autonomic pharmacology endpoint studies
Benefits Researchers Are Exploring (in simple terms)
Mechanisms Under Investigation
Receptor Selectivity
Potent MC4R agonism with MC3R activity; reduced MC1R versus parent melanotan compounds.
Central Signalling
Examined in hypothalamic and limbic neuron culture models.
Autonomic Effects
Documented cardiovascular autonomic changes in controlled pharmacology protocols.
Reconstitution Reference (how to mix it for lab use)
| Common vial size | 10 mg |
| Reconstitution | 1-2 mL BAC water |
| Storage | -20 C, light-protected |
| Binding assays | Nanomolar concentrations typical |
Dosing Schedule Options from Research
Example Options Used in Studies
- Receptor binding assays: single acute exposure at nM concentrations
- Pharmacology research: single-dose or limited repeat-dose protocols in defined cohorts
- Neuronal cultures: 1-24 hour exposure for second-messenger endpoints
- Investigational literature examines on-demand vs. scheduled administration designs
100-Unit Insulin Syringe Conversion Chart
Reconstitution used for these calculations: Calculate concentration (mg/mL) from the reconstitution table above. U-100 insulin syringes: 100 units = 1 mL total volume.
Important: We have already done all the math for you. U-100 insulin syringes are marked in "units" (100 units = 1 mL). Just draw the exact number of units listed below for each dose. No calculations required on your end.
| Dose (mg) | Units on 100-unit syringe (pre-calculated) |
|---|---|
| Use: Units = (desired mg / mg per mL concentration) × 100. See primary literature for exact values. | |
These unit amounts assume the exact concentration listed above. Always double-check your own reconstitution volume against the chart.
Safe Research Cycle Guidelines
Example Cycle References from Research Literature
- Consult published research literature and your institution's approved protocols for recommended cycle lengths, titration, and recovery periods specific to this compound.
Research Notes
PT-141 is studied for CNS melanocortin pathways, not peripheral tanning research.
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